- A rare goblet cell adenocarcinoma arising from Barrett’s esophagus: the first reported case in the esophagus
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Chi Eun Oh, Sung Eun Kim, Sun-Ju Oh
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J Pathol Transl Med. 2024;58(2):81-86. Published online January 8, 2024
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DOI: https://doi.org/10.4132/jptm.2023.12.26
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- Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett’s esophagus.
- Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review
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Sun-Ju Oh, So Hak Chung
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J Pathol Transl Med. 2022;56(3):157-160. Published online January 21, 2022
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DOI: https://doi.org/10.4132/jptm.2021.12.15
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- Chondromyxoid fibroma is a rare bone tumor of cartilaginous origin, representing less than 1% of all bone tumors. It preferentially arises in the eccentric location of the metaphysis of a long tubular bone. Juxtacortical locations are reported infrequently in the long bones and even more rarely in short tubular bones, with only three cases documented. Here we present two new cases of juxtacortical chondromyxoid fibroma in the small bones. One was an intracortical osteolytic lesion of the metatarsal bone of the foot with degenerative atypia that histologically should be differentiated from chondrosarcoma. The other was a phalangeal mass protruding into the interphalangeal joint of the hand, which had been labeled mistakenly as a soft tissue mass preoperatively. These cases illustrated that chondromyxoid fibromas have various the manifestations and should be included in the differential diagnosis of an osteolytic lesion or an exophytic mass in the small bones.
- Rosette-forming epithelioid osteosarcoma in the rib: a rare case of location and morphology
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Sun-Ju Oh
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J Pathol Transl Med. 2021;55(6):406-409. Published online August 3, 2021
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DOI: https://doi.org/10.4132/jptm.2021.06.22
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- The rib is an unusual location for osteosarcoma and is reported in only 2% of all cases. The major histological variants of osteosarcoma are osteoblastic, chondroblastic, and fibroblastic, with a few rare variants including one epithelioid type. This report describes a 44-year-old male with an osteolytic mass in the right seventh rib. Histological examination revealed osteosarcoma with unique features of epithelioid appearance and rosette structures. To the best of our knowledge, this is the first reported case of a rosette-forming osteosarcoma of the rib that showed epithelioid morphology. Despite successful surgery, the patient’s prognosis was poor because this malignancy had an unusual location within the axial skeleton and was a rare histological variant.
- Fibrocartilaginous mesenchymoma with an unusual location in the rib
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Sun-Ju Oh
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J Pathol Transl Med. 2021;55(1):75-78. Published online December 3, 2020
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DOI: https://doi.org/10.4132/jptm.2020.10.08
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- Fibrocartilaginous mesenchymoma is a rare bone tumor, with fewer than 35 cases reported in the literature since 1984. This tumor usually occurs in the long bones of children and adolescents. In the current case, the tumor affected a rib. A 17-year-old boy presented with a mass in the right fifth rib. Radiologic findings revealed an osteolytic mass with cortical destruction and calcification; en bloc resection was performed. The tumor showed three distinct histologic features: bland spindle cell proliferation, benign cartilage nodules, and epiphyseal plate-like enchondral ossification. The pathologic diagnosis was fibrocartilaginous mesenchymoma. The patient remains free of disease 1 year after the surgery. Pathological diagnosis of fibrocartilaginous mesenchymoma can be challenging, especially when the tumor occurs in an unusual site. When any fibro-osseous lesion with a cartilaginous component is encountered, the possibility of fibrocartilaginous mesenchymoma should be considered because of its locally aggressive behavior.
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- Fibrocartilaginous mesenchymoma of pelvis—a potential diagnostic pitfall
Monalisa Hui, Shantveer G. Uppin, Ramakrishna Narayanan, K. Nageshwara Rao, B. Aravind Kumar Skeletal Radiology.2023; 52(4): 791. CrossRef
- Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?
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Sun-Ju Oh, Young-Ok Kim
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J Pathol Transl Med. 2018;52(4):238-242. Published online January 25, 2018
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DOI: https://doi.org/10.4132/jptm.2017.11.21
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- Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.
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- Primary cutaneous mucinous carcinoma of the scalp masquerading as a benign dermatological mass – A case report
Fadi Alnehlaoui, Nafad Mohamed Lotfy Elhadidi, Shafik Fwakhrji, Shekhar V. Shikare, Majid Hassan Alhammadi, Salman Yousuf Guraya International Journal of Surgery Case Reports.2024; 114: 109175. CrossRef - Primary Cutaneous Mucinous Carcinoma: A Review of the Literature
Timothy Freeman, Aaron J. Russell, M. Laurin Council Dermatologic Surgery.2023; 49(12): 1091. CrossRef - A Case of Eccrine Mucinous Carcinoma Involving Scalp
Ramsha Saleem, Sachin Vaidya Cureus.2021;[Epub] CrossRef
- Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior
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Sun-Ju Oh, Minjung Jung, Young-Ok Kim
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J Pathol Transl Med. 2015;49(4):343-345. Published online June 15, 2015
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DOI: https://doi.org/10.4132/jptm.2015.04.27
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7,398
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- Malignant Clinical Course of “Proliferative” Ovarian Struma: Diagnostic Challenges and Treatment Pitfalls
Aleksandra Asaturova, Alina Magnaeva, Anna Tregubova, Vlada Kometova, Yevgeniy Karamurzin, Sergey Martynov, Yuliya Lipatenkova, Leila Adamyan, Andrea Palicelli Diagnostics.2022; 12(6): 1411. CrossRef - Malignant struma ovarii with late recurrence harbouring high microsatellite instability
Su Yun Chung, Jeffrey Chi, Jennifer Park, Veena John, Nagashree Seetharamu BMJ Case Reports.2021; 14(6): e242081. CrossRef - Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii
Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D’Almeida Costa, Américo Delgado Brilhante JBJS Case Connector.2017; 7(4): e82. CrossRef
- Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma
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Su-Mi Kim, Sun-Ju Oh, Bang Hur
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Korean J Pathol. 2012;46(5):429-435. Published online October 25, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.429
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7,704
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- Background
Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma. MethodsWe examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups. ResultsThe low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival. ConclusionsAlthough there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.
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- Expression of Mucoproteins in Gallbladder Cancer
Puneet Kumar, Priyesh Shukla, Soni Kumari, Ruhi Dixit, Gopeshwar Narayan, V. K. Dixit, A. K. Khanna Indian Journal of Surgery.2022; 84(3): 456. CrossRef - Prognostic and clinicopathological value of MUC1 expression in colorectal cancer
Chao Li, Tao Liu, Libin Yin, Didi Zuo, Yuyang Lin, Lei Wang Medicine.2019; 98(9): e14659. CrossRef - Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers
Feng Xu, Fuquan Liu, Hongwei Zhao, Guangyu An, Guosheng Feng Medicine.2015; 94(50): e2286. CrossRef - Increased Expression of CCN2, Epithelial Membrane Antigen, and Fibroblast Activation Protein in Hepatocellular Carcinoma with Fibrous Stroma Showing Aggressive Behavior
Gi Jeong Kim, Hyungjin Rhee, Jeong Eun Yoo, Jung Eun Ko, Jee San Lee, Hyunki Kim, Jin Sub Choi, Young Nyun Park, Philip C. Trackman PLoS ONE.2014; 9(8): e105094. CrossRef - State-of-the-art in the management of locally advanced and metastatic gallbladder cancer
Mairéad G. McNamara, Cristiane Metran-Nascente, Jennifer J. Knox Current Opinion in Oncology.2013; 25(4): 425. CrossRef - Clinicopathological and Prognostic Significance of MUC-2, MUC-4 and MUC-5AC Expression in Japanese Gastric Carcinomas
Li-Jun Xiao, Shuang Zhao, En-Hong Zhao, Xin Zheng, Wen-Feng Gou, Ya-Nan Xing, Yasuo Takano, Hua-Chuan Zheng Asian Pacific Journal of Cancer Prevention.2012; 13(12): 6447. CrossRef
- Clinicopathologic Implications of PIWIL2 Expression in Colorectal Cancer
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Sun-Ju Oh, Su-Mi Kim, Young-Ok Kim, Hee-Kyung Chang
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Korean J Pathol. 2012;46(4):318-323. Published online August 23, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.318
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- Background
There are no established reports about the expression of the Piwil gene, a subfamily of the Piwi gene involved in RNA silencing and self-renewal, in colorectal carcinomas. It is known that the degree of PIWIL2 expression is higher in colorectal carcinomas. But its clinicopathologic significance remains undetermined. This study reassessed the relationship between PIWIL2 expression and the clinicopathologic parameters in colorectal carcinomas. MethodsAn immunohistochemistry
of PIWIL2 expression was done in 60 cases of colorectal carcinoma. This was followed by an analysis of the correlation between PIWIL2 expression and clinicopathologic features and a survival analysis. ResultsThere were 44 cases (73.3%) where the degree of PIWIL2 expression was relatively higher. The high degree of PIWIL2 expression was significantly correlated with the lower degree of differentiation (p=0.039), deep invasion (p=0.019) and perineural invasion (p=0.027). The overall survival was longer in patients with the lower degree of PIWIL2 expression than in those with the higher degree of PIWIL2 expression. ConclusionsOur results showed that the degree of PIWIL2 expression was relatively higher in colorectal carcinomas and it was significantly correlated with variable clinicopathologic indicators for a poor prognosis. This indicates that PIWIL2-positive cells contribute to the progression of colorectal cancer.
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